Physiology AJP: Regulatory, Integrative and Comparative Physiology
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Physiology 22: 269-278, 2007; doi:10.1152/physiol.00009.2007
1548-9213/07 $8.00
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Physiology, Vol. 22, No. 4, 269-278, August 2007
© 2007 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Activity-Dependent Signaling Pathways Controlling Muscle Diversity and Plasticity

Stefano Schiaffino1,2,3, Marco Sandri1,3,4 and Marta Murgia1

1 Department of Biomedical Sciences, University of Padova,
2 Consiglio Nazionale delle Ricerche (CNR) Institute of Neurosciences,
3 Venetian Institute of Molecular Medicine (VIMM), and
4 Dulbecco Telethon Institute, Padova, Italy stefano.schiaffino{at}unipd.it

A variety of fiber types with different contractile and metabolic properties is present in mammalian skeletal muscle. The fiber-type profile is controlled by nerve activity via specific signaling pathways, whose identification may provide potential therapeutic targets for the prevention and treatment of metabolic and neuromuscular diseases.




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