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REVIEW
1 Department of Medicine,
2 Lurie Cancer Center,
3 The Integrated Graduate Program in the Life Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois c-gottardi{at}northwestern.edu
ß-Catenin plays a critical structural role in cadherin-based adhesions and is also an essential co-activator of Wnt-mediated gene expression. The degree to which ß-catenin participates in these two functions is dictated by the availability of ß-catenin binding partners, and an emerging theme is that these binding interactions are regulated by phosphorylation. Inputs from various cell-signaling events can therefore impact ß-catenin function, which may be necessary for the finely tuned adhesive and signaling responses required for tissue morphogenesis.
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