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Physiology 22: 303-309, 2007; doi:10.1152/physiol.00020.2007
1548-9213/07 $8.00
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Physiology, Vol. 22, No. 5, 303-309, October 2007
© 2007 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Phospho-regulation of ß-Catenin Adhesion and Signaling Functions

Rebecca Leadem Daugherty3 and Cara J. Gottardi1,2

1 Department of Medicine,
2 Lurie Cancer Center,
3 The Integrated Graduate Program in the Life Sciences, Feinberg School of Medicine, Northwestern University, Chicago, Illinois c-gottardi{at}northwestern.edu

ß-Catenin plays a critical structural role in cadherin-based adhesions and is also an essential co-activator of Wnt-mediated gene expression. The degree to which ß-catenin participates in these two functions is dictated by the availability of ß-catenin binding partners, and an emerging theme is that these binding interactions are regulated by phosphorylation. Inputs from various cell-signaling events can therefore impact ß-catenin function, which may be necessary for the finely tuned adhesive and signaling responses required for tissue morphogenesis.






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