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Physiology 22: 335-341, 2007; doi:10.1152/physiol.00016.2007
1548-9213/07 $8.00
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Physiology, Vol. 22, No. 5, 335-341, October 2007
© 2007 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

No Potassium, No Acid: K+ Channels and Gastric Acid Secretion

Dirk Heitzmann and Richard Warth

Institute of Physiology, Regensburg, Germany, richard.warth{at}vkl.uni-regensburg.de

The gastric H+-K+-ATPase pumps H+ into the lumen and takes up K+ in parallel. In the acid-producing parietal cells, luminal KCNE2/KCNQ1 K+ channels play a pivotal role in replenishing K+ in the luminal fluid. Inactivation of KCNE2/KCNQ1 channels abrogates gastric acid secretion and dramatically modifies the architecture of gastric mucosa.







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