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Physiology 22: 373-379, 2007; doi:10.1152/physiol.00026.2007
1548-9213/07 $8.00
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Physiology, Vol. 22, No. 6, 373-379, December 2007
© 2007 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Metabolic Control of Proteasome Function

Fengxue Zhang3, Andrew J. Paterson1,3, Ping Huang2, Kai Wang1 and Jeffrey E. Kudlow1,2,3

1 Departments of Physiology and Biophysics,
2 Pharmacology and Toxicology, and
3 Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Alabama at Birmingham, Birmingham, Alabama kudlow{at}uab.edu

Proteasomes are major cellular proteases that are important for protein turnover and cell survival. Dysregulation of proteasome is related to many major human diseases. Regulation of the proteasome is beginning to be understood by the recent findings that proteasomes are modified and regulated by metabolic factors O-GlcNAcylation and PKA phosphorylation.




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