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Physiology 22: 390-400, 2007; doi:10.1152/physiol.00025.2007
1548-9213/07 $8.00
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Physiology, Vol. 22, No. 6, 390-400, December 2007
© 2007 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Tandem Mass Spectrometry in Physiology

Trairak Pisitkun, Jason D. Hoffert, Ming-Jiun Yu and Mark A. Knepper

Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland knep{at}helix.nih.gov

Tandem mass spectrometry coupled to liquid chromatography (LC-MS/MS) allows identification of proteins in a complex mixture without need for protein purification ("shotgun" proteomics). Recent progress in LC-MS/MS-based quantification, phosphoproteomic analysis, and targeted LC-MS/MS using multiple reaction monitoring (MRM) has made LC-MS/MS a powerful tool for the study of cell physiology.






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