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Physiology 23: 17-22, 2008; doi:10.1152/physiol.00042.2007
1548-9213/08 $8.00
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Physiology, Vol. 23, No. 1, 17-22, February 2008
© 2008 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

β-Arrestins: Multifunctional Cellular Mediators

Liza Barki-Harrington1 and Howard A. Rockman2,3,4

1 Department of Biology, University of Haifa, Israel; and
2 Departments of Medicine, Cell
3 Biology, and
4 Molecular Genetics, Duke University Medical Center, Durham, North Carolina, h.rockman{at}duke.edu

Initially thought to play a role only in G-protein-coupled receptor desensitization, β-arrestins are ascribed with new roles such as scaffolding and signaling proteins by their own right. This review explores the many functions of β-arrestins, with an emphasis on their recently identified role as regulators of receptor signaling.




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