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REVIEW
1 Department of Biology, University of Haifa, Israel; and
2 Departments of Medicine, Cell
3 Biology, and
4 Molecular Genetics, Duke University Medical Center, Durham, North Carolina, h.rockman{at}duke.edu
Initially thought to play a role only in G-protein-coupled receptor desensitization, β-arrestins are ascribed with new roles such as scaffolding and signaling proteins by their own right. This review explores the many functions of β-arrestins, with an emphasis on their recently identified role as regulators of receptor signaling.
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