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Physiology 23: 32-40, 2008; doi:10.1152/physiol.00039.2007
1548-9213/08 $8.00
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Physiology, Vol. 23, No. 1, 32-40, February 2008
© 2008 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Calciotropic and Magnesiotropic TRP Channels

Joost G. J. Hoenderop and René J. M. Bindels

Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands r.bindels{at}ncmls.ru.nl

Significant progress has been made into our understanding of the molecular mechanisms responsible for Ca2+ and Mg2+ homeostasis. Members of the transient receptor potential channel (TRP) superfamily proved essential to the maintenance of divalent cation levels by regulating their absorption from renal and intestinal lumina. This review highlights the molecular and functional aspects of these new calciotropic and magnesiotropic TRPs in health and disease.






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