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Physiology 23: 49-57, 2008; doi:10.1152/physiol.00031.2007
1548-9213/08 $8.00
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Physiology, Vol. 23, No. 1, 49-57, February 2008
© 2008 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Potassium Channel Phosphorylation in Excitable Cells: Providing Dynamic Functional Variability to a Diverse Family of Ion Channels

Kang-Sik Park1, Jae-Won Yang1, Edward Seikel1 and James S. Trimmer1,2

1 Section of Neurobiology, Physiology and Behavior, College of Biological Sciences
2 Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, California, jtrimmer{at}ucdavis.edu

Phosphorylation of potassium channels affects their function and plays a major role in regulating cell physiology. Here, we review previous studies of potassium channel phosphorylation, focusing first on studies employing site-directed mutagenesis of recombinant channels expressed in heterologous cells. We then discuss recent mass spectrometric-based approaches to identify and quantify phosphorylation at specific sites on native and recombinant potassium channels, and newly developed mass spectrometric-based techniques that may prove beneficial to future studies of potassium channel phosphorylation, its regulation, and its mechanism of channel modulation.




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