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REVIEW
1 Section of Neurobiology, Physiology and Behavior, College of Biological Sciences
2 Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, California, jtrimmer{at}ucdavis.edu
Phosphorylation of potassium channels affects their function and plays a major role in regulating cell physiology. Here, we review previous studies of potassium channel phosphorylation, focusing first on studies employing site-directed mutagenesis of recombinant channels expressed in heterologous cells. We then discuss recent mass spectrometric-based approaches to identify and quantify phosphorylation at specific sites on native and recombinant potassium channels, and newly developed mass spectrometric-based techniques that may prove beneficial to future studies of potassium channel phosphorylation, its regulation, and its mechanism of channel modulation.
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