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REVIEW

Potassium Channel Phosphorylation in Excitable Cells: Providing Dynamic Functional Variability to a Diverse Family of Ion Channels

Kang-Sik Park¹, Jae-Won Yang¹, Edward Seikel¹ and James S. Trimmer^1,2

¹ Section of Neurobiology, Physiology and Behavior, College of Biological Sciences
² Department of Physiology and Membrane Biology, School of Medicine, University of California, Davis, California, jtrimmer{at}ucdavis.edu

Phosphorylation of potassium channels affects their function and plays a major role in regulating cell physiology. Here, we review previous studies of potassium channel phosphorylation, focusing first on studies employing site-directed mutagenesis of recombinant channels expressed in heterologous cells. We then discuss recent mass spectrometric-based approaches to identify and quantify phosphorylation at specific sites on native and recombinant potassium channels, and newly developed mass spectrometric-based techniques that may prove beneficial to future studies of potassium channel phosphorylation, its regulation, and its mechanism of channel modulation.