HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Szabadkai, G. Articles by Duchen, M. R. PubMed PubMed Citation Articles by Szabadkai, G. Articles by Duchen, M. R.

REVIEW

Mitochondria: The Hub of Cellular Ca²⁺ Signaling

György Szabadkai and Michael R. Duchen

Department of Physiology, Mitochondrial Biology Group, University College London, London, United Kingdom g.szabadkai{at}ucl.ac.uk

Mitochondria couple cellular metabolic state with Ca²⁺ transport processes. They therefore control not only their own intra-organelle [Ca²⁺], but they also influence the entire cellular network of cellular Ca²⁺ signaling, including the endoplasmic reticulum, the plasma membrane, and the nucleus. Through the detailed study of mitochondrial roles in Ca²⁺ signaling, a remarkable picture of inter-organelle communication has emerged. We here review the ways in which this system provides integrity and flexibility for the cell to cope with the countless demands throughout its life cycle and discuss briefly the mechanisms through which it can also drive cell death.