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Physiology 23: 151-159, 2008; doi:10.1152/physiol.00043.2007
1548-9213/08 $8.00
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Physiology, Vol. 23, No. 3, 151-159, June 2008
© 2008 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

The Role of Calmodulin Kinase II in Myocardial Physiology and Disease

Luis F. Couchonnal1 and Mark E. Anderson1,2

1 Departments of Internal Medicine and
2 Molecular Physiology and Biophysics, Division of Cardiovascular Medicine, University of Iowa, Carver College of Medicine, Iowa City, Iowa, mark-e-anderson{at}uiowa.edu

The multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates a rich variety of downstream targets in heart. Ca2+ homeostatic proteins are important CaMKII targets that support myocardial excitation-contraction coupling. Under stress conditions, excessive CaMKII activity promotes heart failure and arrhythmias, in part through actions at Ca2+ homeostatic proteins. Here, we briefly review the molecular and cellular physiology of CaMKII in myocardium.






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