Physiology Journal of Neurophysiology
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Physiology 23: 160-170, 2008; doi:10.1152/physiol.00041.2007
1548-9213/08 $8.00
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Physiology, Vol. 23, No. 3, 160-170, June 2008
© 2008 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Signaling in Muscle Atrophy and Hypertrophy

Marco Sandri

Department of Biomedical Sciences, University of Padova; Dulbecco Telethon Institute; and Venetian Institute of Molecular Medicine, Padova, Italy marco.sandri{at}unipd.it

Muscle performance is influenced by turnover of contractile proteins. Production of new myofibrils and degradation of existing proteins is a delicate balance, which, depending on the condition, can promote muscle growth or loss. Protein synthesis and protein degradation are coordinately regulated by pathways that are influenced by mechanical stress, physical activity, availability of nutrients, and growth factors. Understanding the signaling that regulates muscle mass may provide potential therapeutic targets for the prevention and treatment of muscle wasting in metabolic and neuromuscular diseases.






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