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Physiology 23: 194-204, 2008; doi:10.1152/physiol.00009.2008
1548-9213/08 $8.00
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Physiology, Vol. 23, No. 4, 194-204, August 2008
© 2008 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Presenilins: Members of the {gamma}-Secretase Quartets, But Part-Time Soloists Too

Tomoko Wakabayashi1,2 and Bart De Strooper1,2

1 Department for Developmental and Molecular Genetics, VIB, Leuven, and
2 Center for Human Genetics, KULeuven, Leuven, Bart.destrooper{at}med.kuleuven.be

The presenilins in combination with other proteins generate different {gamma}-secretases, which are involved in the regulated intramembrane proteolysis of a variety of proteins. Understanding the specificity and regulation of these proteases will potentially lead to novel therapeutics for Alzheimer’s disease and cancer. Presenilins appear also to exert additional functions outside of the {gamma}-secretase quartets, which needs further investigation.






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