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Physiology 23: 238-247, 2008; doi:10.1152/physiol.00018.2008
1548-9213/08 $8.00
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Physiology, Vol. 23, No. 5, 238-247, October 2008
© 2008 Int. Union Physiol. Sci./Am. Physiol. Soc.

EMERGING TECHNOLOGY

Nanoengineering Ion Channels for Optical Control

Pau Gorostiza1 and Ehud Y. Isacoff2

1 Institut de Bioenginyeria de Catalunya (IBEC), Institució Catalana de Recerca i Estudis Avançats (ICREA), and CIBER-BBN, Parc Científic de Barcelona, Barcelona, Spain; and
2 Department of Molecular and Cell Biology, Divisions of Material and Physical Bioscience, Lawrence Berkeley National Laboratory, University of California at Berkeley, Berkeley, California ehud{at}berkeley.edu

Chemical modification with photoisomerizable tethered ligands endows proteins with sensitivity to light. These optically actuated proteins are revolutionizing research in biology by making it possible to manipulate biological processes noninvasively and with unprecedented spatiotemporal resolution.




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