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Physiology 23: 322-332, 2008; doi:10.1152/physiol.00028.2008
1548-9213/08 $8.00
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Physiology, Vol. 23, No. 6, 322-332, December 2008
© 2008 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Heterodimers and Receptor Mosaics of Different Types of G-Protein-Coupled Receptors

Kjell Fuxe1, Daniel Marcellino1, Diego Guidolin2, Amina S. Woods3 and Luigi F. Agnati4

1 Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden;
2 Department of Anatomy and Physiology, University of Padua, Padua, Italy;
3 National Institute on Drug Abuse, NIH, DHHS, Baltimore, Maryland; and
4 Department of BioMedical Sciences, University of Modena, Modena, and IRCCS Lido, Venice, Italy Kjell.Fuxe{at}ki.se

Through an assembly of interacting GPCRs, heterodimers and high-order heteromers (termed receptor mosaics) are formed and lead to changes in the agonist recognition, signaling, and trafficking of participating receptors via allosteric mechanisms, sometimes involving the appearance of cooperativity. This field has now become a major research area, and this review deals with their physiology being integrators of receptor signaling in the CNS and their use as targets for novel drug development based on their unique pharmacology.






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