Physiology Journal of Applied Physiology
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Physiology 24: 36-44, 2009; doi:10.1152/physiol.00036.2008
1548-9213/09 $8.00
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Physiology, Vol. 24, No. 1, 36-44, February 2009
© 2009 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Intercellular Communication in Atherosclerosis

Laurent Burnier1,2,3, Pierre Fontana2, Anne Angelillo-Scherrer3 and Brenda R. Kwak1

1 Department of Internal Medicine, Division of Cardiology,
2 Department of Internal Medicine, Division of Angiology and Hemostasis, Geneva University Hospitals and University of Geneva, Geneva, Switzerland; and
3 Service and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland Brenda.KwakChanson{at}unige.ch

Cell-to-cell communication is a process necessary for physiological tissue homeostasis and appears often altered during disease. Gap junction channels, formed by connexins, allow the direct intercellular communication between adjacent cells. After a brief review of the pathophysiology of atherosclerosis, we will discuss the role of connexins throughout the different stages of the disease.




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[Abstract] [Full Text] [PDF]


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