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REVIEW

Maternal Uterine Vascular Remodeling During Pregnancy

George Osol¹ and Maurizio Mandala²

¹ Department of Obstetrics and Gynecology, University of Vermont College of Medicine, Burlington, Vermont; and
² University of Calabria, Cosenza, Italy George.Osol{at}uvm.edu

Sufficient uteroplacental blood flow is essential for normal pregnancy outcome and is accomplished by the coordinated growth and remodeling of the entire uterine circulation, as well as the creation of a new fetal vascular organ: the placenta. The process of remodeling involves a number of cellular processes, including hyperplasia and hypertrophy, rearrangement of existing elements, and changes in extracellular matrix. In this review, we provide information on uterine blood flow increases during pregnancy, the influence of placentation type on the distribution of uterine vascular resistance, consideration of the patterns, nature, and extent of maternal uterine vascular remodeling during pregnancy, and what is known about the underlying cellular mechanisms.

This article has been cited by other articles:

				N. I. Gokina, O. Y. Kuzina, R. Fuller, and G. Osol Local Uteroplacental Influences are Responsible for the Induction of Uterine Artery Myogenic Tone during Rat Pregnancy Reproductive Sciences, November 1, 2009; 16(11): 1072 - 1081. [Abstract] [PDF]