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Physiology 24: 107-116, 2009; doi:10.1152/physiol.00038.2008
1548-9213/09 $8.00
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Physiology, Vol. 24, No. 2, 107-116, April 2009
© 2009 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Erythrocytes: Oxygen Sensors and Modulators of Vascular Tone

Mary L. Ellsworth1, Christopher G. Ellis2, Daniel Goldman2, Alan H. Stephenson1, Hans H. Dietrich3 and Randy S. Sprague1

1 Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, St. Louis, Missouri;
2 Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada; and
3 Department of Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri ellsworthm{at}slu.edu

Through oxygen-dependent release of the vasodilator ATP, the mobile erythrocyte plays a fundamental role in matching microvascular oxygen supply with local tissue oxygen demand. Signal transduction within the erythrocyte and microvessels as well as feedback mechanisms controlling ATP release have been described. Our understanding of the impact of this novel control mechanism will rely on the integration of in vivo experiments and computational models.




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