HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Huh, M. S. Articles by Picketts, D. J. Search for Related Content PubMed PubMed Citation Articles by Huh, M. S. Articles by Picketts, D. J.

REVIEW

SCO-ping Out the Mechanisms Underlying the Etiology of Hydrocephalus

Michael S. Huh^1,*, Matthew A. M. Todd^2,* and David J. Picketts²

¹ Regenerative Medicine Program, Ottawa Health Research Institute, and
² Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada dpicketts{at}ohri.ca

The heterogeneous nature of congenital hydrocephalus has hampered our understanding of the molecular basis of this common clinical problem. However, disease gene identification and characterization of multiple transgenic mouse models has highlighted the importance of the subcommissural organ (SCO) and the ventricular ependymal (vel) cells. Here, we review how altered development and function of the SCO and vel cells contributes to hydrocephalus.

^* M. S. Huh and M. A. M. Todd contributed equally to this manuscript.