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Physiology 24: 78-87, 2009; doi:10.1152/physiol.00041.2008
1548-9213/09 $8.00
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Physiology, Vol. 24, No. 2, 78-87, April 2009
© 2009 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

AKAP-Scaffolding Proteins and Regulation of Cardiac Physiology

J. R. H. Mauban1, M. O’Donnell1, S. Warrier1, S. Manni3,4 and M. Bond1,2

1 Departments of Physiology, and
2 Medicine School of Medicine, University of Maryland Baltimore, Baltimore, Maryland;
3 Department of Clinical and Experimental Medicine, Hematology-Immunology Branch, University of Padova, Padova; and
4 Venetian Institute of Molecular Medicine (VIMM), Padova, Italy mbond{at}som.umaryland.edu

A kinase anchoring proteins (AKAPs) compose a growing list of diverse but functionally related proteins defined by their ability to bind to the regulatory subunit of protein kinase A. AKAPs perform an integral role in the spatiotemporal modulation of a multitude of cellular signaling pathways. This review highlights the extensive role of AKAPs in cardiac excitation/contraction coupling and cardiac physiology. The literature shows that particular AKAPs are involved in cardiac Ca2+ influx, release, reuptake, and myocyte repolarization. Studies have also suggested roles for AKAPs in cardiac remodeling. Transgenic studies show functional effects of AKAPs, not only in the cardiovascular system but in other organ systems as well.




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