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Physiology 24: 186-191, 2009; doi:10.1152/physiol.00005.2009
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Physiology, Vol. 24, No. 3, 186-191, June 2009
© 2009 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Hypertonic Stress in the Kidney: A Necessary Evil

Min Seong Kwon, Sun Woo Lim and H. Moo Kwon

Department of Medicine, University of Maryland, Baltimore, Maryland mkwon{at}medicine.umaryland.edu

The interstitium of the renal medulla is hypertonic, imposing deleterious effects on local cells. At the same time, the hypertonicity provides osmotic gradient for water reabsorption and is a local signal for tissue-specific gene expression and differentiation of the renal medulla, which is a critical organ for water homeostasis.






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