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Physiology 24: 245-249, 2009; doi:10.1152/physiol.00009.2009
1548-9213/09 $8.00
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Physiology, Vol. 24, No. 4, 245-249, August 2009
© 2009 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

What’s New About Osmotic Regulation of Glycerophosphocholine

Morgan Gallazzini and Maurice B. Burg

Department of Health and Human Services, Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland maurice_burg{at}nih.gov

Glycerophosphocholine is an abundant renal medullary organic osmolyte that protects renal medullary cells from the high interstitial concentrations of NaCl and urea to which they are normally exposed. We consider the metabolism of glycerophosphocholine, its osmotic regulation, and the recently discovered molecular identity of the enzymes that osmoregulate its abundance.






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Copyright © 2009 by the Int. Union Physiol. Sci./Am. Physiol. Soc.