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REVIEW

Role of Extracellular Adenosine in Acute Lung Injury

Tobias Eckle¹, Michael Koeppen¹ and Holger K. Eltzschig^1,2

¹ Department of Anesthesiology, Mucosal Inflammation Program, University of Colorado Denver, Aurora, Colorado; and
² Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Tübingen, Germany, holger.eltzschig{at}ucdenver.edu

Acute lung injury (ALI) is a lung disease characterized by pulmonary edema and severe hypoxia. The past decade hosted a search for endogenous mechanisms controlling lung inflammation and pulmonary edema during ALI. As such, recent evidence indicates extracellular adenosine in orchestrating the resolution of pulmonary edema and inflammation during ALI.

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