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Physiology 24: 332-341, 2009; doi:10.1152/physiol.00031.2009
1548-9213/09 $8.00
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Physiology, Vol. 24, No. 6, 332-341, December 2009
© 2009 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Roles of Phospholipase C Isozymes in Organogenesis and Embryonic Development

Yoshikazu Nakamura and Kiyoko Fukami

Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan kfukami{at}ls.toyaku.ac.jp

Phosphoinositide metabolism is an important intracellular signaling system that regulates a variety of cellular functions. Phospholipase C (PLC) is a key enzyme in this system. Recent studies on genetically manipulated mice have clarified the functions of PLC in vivo. This review focuses on the roles of PLC in organogenesis and embryonic development.






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