Physiology Cambridge Electronic Design Limited
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Physiology 24: 342-356, 2009; doi:10.1152/physiol.00023.2009
1548-9213/09 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Google Scholar
Right arrow Articles by Puetz, S.
Right arrow Articles by Pfitzer, G.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Puetz, S.
Right arrow Articles by Pfitzer, G.
Physiology, Vol. 24, No. 6, 342-356, December 2009
© 2009 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Regulation of Smooth Muscle Contraction by Small GTPases

Sandra Puetz, Lubomir T. Lubomirov and Gabriele Pfitzer

Institut für Vegetative Physiologie, Universitaet Koeln, Koeln, Germany, Gabriele.Pfitzer{at}uni-koeln.de

Next to changes in cytosolic [Ca2+], members of the Rho subfamily of small GTPases, in particular Rho and its effector Rho kinase, also known as ROK or ROCK, emerged as key regulators of smooth muscle function in health and disease. In this review, we will focus on the regulation of the contractile machinery by Rho/ROK signaling and its interaction with PKC and cyclic nucleotide signaling. We will briefly discuss the emerging evidence that remodeling of cortical actin is necessary for contraction.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2009 by the Int. Union Physiol. Sci./Am. Physiol. Soc.