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Physiology 24: 377-386, 2009; doi:10.1152/physiol.00030.2009
1548-9213/09 $8.00
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Physiology, Vol. 24, No. 6, 377-386, December 2009
© 2009 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

The Rocking Bundle: A Mechanism for Ion-Coupled Solute Flux by Symmetrical Transporters

Lucy R. Forrest1 and Gary Rudnick2

1 Computational Structural Biology, Max Planck Institute for Biophysics, Frankfurt, Germany; and
2 Yale University School of Medicine, New Haven, Connecticut gary.rudnick{at}yale.edu

Crystal structures of the bacterial amino acid transporter LeuT have provided the basis for understanding the conformational changes associated with substrate translocation by a multitude of transport proteins with the same fold. Biochemical and modeling studies led to a "rocking bundle" mechanism for LeuT that was validated by subsequent transporter structures. These advances suggest how coupled solute transport might be defined by the internal symmetry of proteins containing inverted structural repeats.






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