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Physiology 25: 16-26, 2010; doi:10.1152/physiol.00034.2009
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Physiology, Vol. 25, No. 1, 16-26, February 2010
© 2010 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Rho Signaling and Tight Junction Functions

Steve Terry, Mei Nie, Karl Matter and Maria S. Balda

Department of Cell Biology, UCL Institute of Ophthalmology, University College London, London, United Kingdom, m.balda{at}ucl.ac.uk

Tight junctions are heteromeric protein complexes that act as signaling centers by mediating the bidirectional transmission of information between the environment and the cell interior to control paracellular permeability and differentiation. Insight into tight junction-associated signaling mechanisms is of fundamental importance for our understanding of the physiology of epithelia and endothelia in health and disease.






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