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Physiology 25: 27-40, 2010; doi:10.1152/physiol.00039.2009
1548-9213/10 $8.00
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Physiology, Vol. 25, No. 1, 27-40, February 2010
© 2010 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Voltage-Gated Proton Channels Find Their Dream Job Managing the Respiratory Burst in Phagocytes

Thomas E. DeCoursey

Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois tdecours{at}rush.edu

The voltage-gated proton channel bears surprising resemblance to the voltage-sensing domain (S1–S4) of other voltage-gated ion channels but is a dimer with two conduction pathways. The proton channel seems designed for efficient proton extrusion from cells. In phagocytes, it facilitates the production of reactive oxygen species by NADPH oxidase.






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