Physiology Journal of Neurophysiology
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Physiology 25: 41-49, 2010; doi:10.1152/physiol.00033.2009
1548-9213/10 $8.00
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Physiology, Vol. 25, No. 1, 41-49, February 2010
© 2010 Int. Union Physiol. Sci./Am. Physiol. Soc.

REVIEW

Regulation of Ionotropic Glutamate Receptors by Their Auxiliary Subunits

Susumu Tomita

Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR), Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut Susumu.Tomita{at}yale.edu

Glutamate receptors are major excitatory receptors in the brain. Recent findings have established auxiliary subunits of glutamate receptors as critical modulators of synaptic transmission, synaptic plasticity, and neurological disorder. The elucidation of the molecular rules governing glutamate receptors and subunits will improve our understanding of synapses and of neural-circuit regulation in the brain.






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