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PPAR Modulation of Kinase-Linked Receptor Signaling in Physiology and Disease

Nicolas Rotman and Walter Wahli

Center for Integrative Genomics, National Research Center "Frontiers in Genetics," University of Lausanne, Lausanne, Switzerland

walter.wahli{at}unil.ch

Kinase-linked receptors and nuclear receptors connect external cues to gene transcription. Among nuclear receptors, peroxisome proliferator-activated receptors (PPARs) are of special interest in relation to widespread human diseases. Mapping out connections between PPARs and kinase-linked receptor signaling is central to better understand physiological and pathophysiological processes and to better define therapeutic strategies. This is the aim of the present review.

Work performed in the authors' laboratory was supported by the Swiss National Science Foundation (through individual research grants and the National Center of Competence in Research Program Frontiers in Genetics), the State of Vaud, and the Bonizzi-Theler-Stiftung.