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News Physiol Sci 3: 1-5, 1988;
1548-9213/88 $5.00
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News in Physiological Sciences, Vol 3, 1-5, Copyright © 1988 by International Union of Physiological Sciences

ARTICLES

Chemical Messengers and Their Coexistence in Individual Neurons

DE Millhorn and T Hokfelt

The original concept of chemical neural transmission was based on the assumed principle that individual neurons utilize only one type of neurotransmitter. There is now histological evidence that single nerve cells in both the central and the peripheral nervous system often contain multiple chemical messengers. This article describes the evidence for and the functional significance of multiple messengers in synaptic transmission.


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