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News Physiol Sci 3: 46-49, 1988;
1548-9213/88 $5.00
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News in Physiological Sciences, Vol 3, 46-49, Copyright © 1988 by International Union of Physiological Sciences

ARTICLES

Urine Concentration and the Length of the Renal Papilla

L Greenwald and D Stetson

Countercurrent multiplier theory predicts that the maximum urine concentration should be directly related to the length of the loop of Henle. However, those small rodents that achieve very high urine concentrations have much shorter loops than large mammals that produce far lower concentrations. To resolve this contradiction, we propose that the high mass-specific metabolic rates of small mammals make their kidneys capable of the intense active transport required to achieve high urine concentrations.




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