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News Physiol Sci 3: 49-53, 1988;
1548-9213/88 $5.00
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News in Physiological Sciences, Vol 3, 49-53, Copyright © 1988 by International Union of Physiological Sciences

ARTICLES

Evolution of Gonadotropin-Releasing Hormone: Multiple Usage of a Peptide

RP Millar and JA King

Gonadotropin-releasing hormone was originally isolated as a brain peptide hormone that stimulates the reproductive system by releasing gonadotropins from the anterior pituitary gland. However, it is now clear that during evolution this peptide has been subject to gene duplication and structural changes and has been recruited for diverse regulatory functions: as a neurotransmitter in the central and sympathetic nervous sytems, as a paracrine regulator in the gonads and placenta, and as an autocrine regulator in tumor cells.


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Gonadotropin-Releasing Hormone Receptors
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S. C. Sealfon, H. Weinstein, and R. P. Millar
Molecular Mechanisms of Ligand Interaction with the Gonadotropin-Releasing Hormone Receptor
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