Physiology AJP: Renal Physiology
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News Physiol Sci 3: 57-61, 1988;
1548-9213/88 $5.00
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News in Physiological Sciences, Vol 3, 57-61, Copyright © 1988 by International Union of Physiological Sciences

ARTICLES

Scrambling Membrane Phospholipids and Local Control of Blood Clotting

RFA Zwaal

The membrane phospholipids of circulating blood platelets and red cells are asymmetrically arranged with virtually all phosphatidylserine on the inside. Stimulation of platelets by a variety of agents causes redistribution of the phospholipids with phosphatidylserine appearing on the outside. This contributes to a charged surface where local clotting reactions are greatly accelerated. Phospholipids breaking off from sickled red cells contribute similarly to intravascular clotting in the crisis phase of sickle cell disease.




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