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News Physiol Sci 3: 117-120, 1988;
1548-9213/88 $5.00
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News in Physiological Sciences, Vol 3, 117-120, Copyright © 1988 by International Union of Physiological Sciences

ARTICLES

Capillary Growth: Role of Mechanical Factors

O Hudlicka

Although various growth factors initiate angiogenesis under pathological circumstances, vessel growth in physiological conditions (e.g., development, training) is related to increased blood flow. This article stresses the role of blood flow in the stimulation of capillary growth in skeletal muscles and in the heart. Also discussed are various components (blood pressure, wall tension, shear stress, blood cells-endothelium interaction) possibly involved in angiogenesis.


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