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News Physiol Sci 3: 84-88, 1988;
1548-9213/88 $5.00
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News in Physiological Sciences, Vol 3, 84-88, Copyright © 1988 by International Union of Physiological Sciences

ARTICLES

New Concepts in Chronopharmacology

A Reinberg

Modern chronopharmacology investigates how drug effects vary with biological timing and endogenous periodicities. The goal is to improve the understanding of periodic and thus predictable changes in drug effects, and a specific aim is to solve problems of drug optimization. Knowledge of those administration times that coincide with the highest effectiveness and/or tolerance is required to optimize both timing and dosage of a medication.


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