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News Physiol Sci 3: 164-167, 1988;
1548-9213/88 $5.00
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News in Physiological Sciences, Vol 3, 164-167, Copyright © 1988 by International Union of Physiological Sciences

ARTICLES

Cerebral Microcirculation

WG Mayhan, FM Faraci, GL Baumbach and DD Heistad

Three concepts are summarized. First, cerebral microvascular pressure, which can be regulated independently from cerebral blood flow, may have important physiological effects. Second, the blood-brain barrier is more vulnerable to disruption in venules than in capillaries or arterioles during acute hypertension. Third, cerebral arterioles are protected during chronic hypertension by a surprising combination of vascular hypertrophy, remodeling of the vessel wall, and a paradoxical increase in distensibility.




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