Physiology AJP: Gastrointestinal and Liver Physiology
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News Physiol Sci 3: 185-189, 1988;
1548-9213/88 $5.00
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News in Physiological Sciences, Vol 3, 185-189, Copyright © 1988 by International Union of Physiological Sciences

ARTICLES

Platelet 5-Hydroxytryptamine and Vascular Adrenergic Nerves

RA Cohen

Platelets contain and release large amounts of 5-hydroxytryptamine that can influence the function of vascular adrenergic nerves. The immediate effect on neuronal function of low concentrations of the amine is to inhibit norepinephrine release. 5-Hydroxytryptamine may also be accumulated by the same uptake mechanism that reaccumulates norepinephrine into the adrenergic nerve endings. In diseased blood vessels where platelet aggregation occurs, 5-hydroxytryptamine may therby assume an alternative transmitter role, altering the function of the sympathetic nerves.




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