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News Physiol Sci 3: 204-206, 1988;
1548-9213/88 $5.00
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News in Physiological Sciences, Vol 3, 204-206, Copyright © 1988 by International Union of Physiological Sciences

ARTICLES

Neural Transplantation in Animal Models of Neurodegenerative Disesase

TJ Collier and R, Sladek John Jr.

Interest in neural transplantation research has increased greatly in the past five years. Although this procedure initially was viewed as a research tool for studying neuronal development, it is gaining attention as a potential therapeutic intervention. Indeed, replacement of chemically defined neurons in animal models of the neurodegeneration that occurs in Parkinson's disease and Alzheimer's disease indicates that grafted fetal neurons survive transplantation, integrate with the host brain, and produce a sustained improvement of motor function and memory performance.




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