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News Physiol Sci 3: 219-222, 1988;
1548-9213/88 $5.00
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News in Physiological Sciences, Vol 3, 219-222, Copyright © 1988 by International Union of Physiological Sciences

ARTICLES

Ca2+-Mg2+-ATPase Calcium Pumps in the Kidney

R Kumar, JT Penniston and JL Borke

Epitopes of the calmodulin-sensitive erythrocyte Ca2+-Mg2+-ATPase enzyme were found exclusively in basolateral membranes of distal tubule cells of the human and rat kidney;other kidney segments did not contain this enzyme in detectable amounts. The calmodulin-sensitive Ca2+-Mg2+-ATPase acts as a calcium pump in the red cell and other tissues. Its presence in the kidney distal tubule, a site where hormone-sensitive calcium transport is known to occur, raises the possibility that this enzyme may act as a hormone-regulated pump in this nephron segment.




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