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News Physiol Sci 3: 235-241, 1988;
1548-9213/88 $5.00
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News in Physiological Sciences, Vol 3, 235-241, Copyright © 1988 by International Union of Physiological Sciences

ARTICLES

Two Interacting Signal Transduction Pathways Regulate Collecting Duct Water Transport

Y Ando, HR Jacobson and MD Breyer

Receptor-mediated signal transduction occurs through phosphatidylinositol bisphosphate (PIP2) breakdown and activation of adenylate cyclase interacting to regulate cell function. Current studies suggest that hormone-stimulated PIP2 breakdown modulates the classic cyclic AMP-mediated hydrosmotic action of vasopressin through separate mechanisms attributable to activation of protein kinase C, elevation of intracellular Ca2+ concentration, and generation of arachidonate metabolites.


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