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News Physiol Sci 4: 13-17, 1989;
1548-9213/89 $5.00
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News in Physiological Sciences, Vol 4, 13-17, Copyright © 1989 by International Union of Physiological Sciences

ARTICLES

Neuropeptide Y: Sympathetic Cotransmitter and Modulator?

JM Lundberg, J Pernow and JS Lacroix

Neuropeptide Y (NPY) exerts potent vasoconstrictor activity and is coreleased with noradrenaline from sympathetic nerves, mainly on a high degree of activation. It may contribute to the vasoconstriction on high-frequency sympathetic stimulation during control conditions and mediate the long-lasting responses evoked by nerve stimulation in the absence of noradrenaline. NPY enhances the vasomotor effects to noradrenaline and inhibits its release from perivascular nerves. NPY probably is a cotransmitter in sympathetic vascular control.


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