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News Physiol Sci 4: 37-42, 1989;
1548-9213/89 $5.00
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News in Physiological Sciences, Vol 4, 37-42, Copyright © 1989 by International Union of Physiological Sciences

ARTICLES

Membrane Remodelling During Reticulocyte Maturation

RM Johnstone and K Teng

During maturation, reticulocytes lose many membrane functions, including the transferrin receptor. Immunocytochemical studies reveal that after endocytosis the transferrin receptor (and many other membrane proteins) is packaged into multivesicular bodies. The vesicular contents are externalized by exocytosis. The specificity of such membrane processing underlies the changing properties of the cells' surfaces.




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