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News Physiol Sci 4: 94-97, 1989;
1548-9213/89 $5.00
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News in Physiological Sciences, Vol 4, 94-97, Copyright © 1989 by International Union of Physiological Sciences


ARTICLES

Calcium Signalling System Triggered by INsulin-Like Growth Factor II

I Nishimoto and I Kojima

In BALB/c 3T3 fibroblast, the insulin-like growth factor (IGF-II) stimulates DNA replication when added to cells pretreated sequentially with platelet-derived and epidermal growth factors. In these cells, IGF-II increases calcium influx by opening a voltage-independent calcium-permeable channel, and calcium influx is an intracellular message of the IGF-II action.


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Genes Dev.Home page
D A Rappolee, K S Sturm, O Behrendtsen, G A Schultz, R A Pedersen, and Z Werb
Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.
Genes & Dev., June 1, 1992; 6(6): 939 - 952.
[Abstract] [PDF]




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