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News Physiol Sci 4: 130-133, 1989;
1548-9213/89 $5.00
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News in Physiological Sciences, Vol 4, 130-133, Copyright © 1989 by International Union of Physiological Sciences


ARTICLES

Serotonin and Amplification Mechanisms in Platelet Reactions

FFP De Clerck

Platelets react to aggregate or adhere with different intensities depending on the nature of the challenge. Amplification between, rather than individual potencies of, agonists determines their importance during hemostasis or thrombus formation. Such amplification explains why serotonin is an important vector in platelet-vessel wall interactions.


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H. Kawano, H. Tsuji, H. Nishimura, S. Kimura, S. Yano, N. Ukimura, Y. Kunieda, M. Yoshizumi, T. Sugano, K. Nakagawa, et al.
Serotonin induces the expression of tissue factor and plasminogen activator inhibitor-1 in cultured rat aortic endothelial cells
Blood, March 15, 2001; 97(6): 1697 - 1702.
[Abstract] [Full Text] [PDF]




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