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News in Physiological Sciences, Vol 4, 202-205, Copyright © 1989 by International Union of Physiological Sciences
ARTICLES |
FJ Haddy
Acute volume expansion and low-renin hypertension endow the plasma with the capacity to inhibit Na+-K+-ATPase, cause natriuresis, sensitize blood vessels to vasoconstrictor agents, and raise blood pressure. Digoxin-like immunoreactivity has been detected in the plasma under both circumstances. These findings suggest the existence of an endogenous "digitalis" that is relevant to volume and blood pressure control.
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