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News Physiol Sci 4: 225-230, 1989;
1548-9213/89 $5.00
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News in Physiological Sciences, Vol 4, 225-230, Copyright © 1989 by International Union of Physiological Sciences

ARTICLES

Gating Properties and Modulation of Na Channels

B Nilius

Na channels mediate a fast transfer of information in electrically excitable cells. The transition between open-closed transformations of the channel protein (gating) can be described by voltage-dependent transitions between at least four conformational states. Specialized regions within the channel molecule are involved in gating and pharmacological modulation.




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