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News Physiol Sci 4: 242-245, 1989;
1548-9213/89 $5.00
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News in Physiological Sciences, Vol 4, 242-245, Copyright © 1989 by International Union of Physiological Sciences

ARTICLES

The Control of Hemoglobin-Oxygen Binding in Vertebrate Animals

RMG Wells

The affinity of blood for O2 can now be explained in terms of the interaction of the hemoglobin molecule with cofactors. Recent advances in comparative physiology suggest that short-term compensatory changes in blood O2 affinity, which greatly alter the efficiency of the O2-delivery system in response to hypoxia, are typical for vertebrates. Control of O2 delivery by red blood cell organic phosphates is best interpreted in terms of plasticity of the system, rather than as an adaptive feature responsive to evolutionary selection pressure.




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