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News Physiol Sci 5: 67-70, 1990;
1548-9213/90 $5.00
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News in Physiological Sciences, Vol 5, 67-70, Copyright © 1990 by International Union of Physiological Sciences

ARTICLES

Adenosine: A Retaliatory Metabolite or Not?

AC Newby, Y Worku, P Meghji, M Nakazawa and AC Skladanowski

Adenosine has been called a "retaliatory metabolite", since its physiological actions have a common tendency to redress an imbalance between energy demand and availability. Its formation is linked directly to the net breakdown of cytosolic ATP. This hypothesis is still useful to explain much of the physiology of adenosine but is challenged by evidence for adenosine formation from extracellular ATP.


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