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News Physiol Sci 5: 143-147, 1990;
1548-9213/90 $5.00
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News in Physiological Sciences, Vol 5, 143-147, Copyright © 1990 by International Union of Physiological Sciences

ARTICLES

ATP-Regulated K+ Channels and Diabetes Mellitus

P Rorsman, P-O Berggren, K Bokvist and S Efendic

Glucose-stimulated insulin secretion from pancreatic Beta-cells is dependent on closure of ATP-regulated K+ channels. These channels are selectively blocked by hypoglycaemic sulfonylureas, compounds used in treatment of non-insulin-dependent diabetes mellitus (NIDDM). This suggests that NIDDM may result from defective K+-channel regulation.


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