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News Physiol Sci 5: 212-215, 1990;
1548-9213/90 $5.00
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News in Physiological Sciences, Vol 5, 212-215, Copyright © 1990 by International Union of Physiological Sciences

ARTICLES

Endothelium-Derived Hyperpolarizing Factor (EDHF): An Endogenous Potassium-Channel Activator

H Suzuki and G Chen

Acetylcholine hyperpolarizes the membrane of vascular smooth muscles by increasing potassium permeability, the response being mediated by an endothelium-derived hyperpolarizing factor (EDHF). The membrane hyperpolarization produced by EDHF is therefore one of the components contributing to endothelium-dependent relaxation of vascular smooth muscles.




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